Iupac name of pantoprazole sodium sesquihydrate

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Pantoprazole Sodium Sesquihydrate is a pharmaceutical compound known for its potent acid-suppressing properties. The Iupac name of this substance is (R)-6-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole sodium sesquihydrate.

Discover the benefits of Pantoprazole Sodium Sesquihydrate and improve your digestive health today!

Chemical Properties

Pantoprazole Sodium Sesquihydrate is a white to off-white crystalline powder with a molecular formula of C16H15F2N3NaO4S•1.5H2O. It is freely soluble in water and practically insoluble in organic solvents. The compound has a molecular weight of 432.4 g/mol and is stable under normal conditions.

The chemical structure of pantoprazole sodium sesquihydrate consists of a substituted benzimidazole ring attached to a sulfinyl group. The substitution pattern in the benzimidazole ring contributes to the specificity and potency of pantoprazole as a proton pump inhibitor.

The presence of the sesquihydrate form indicates that the compound contains one and a half molecules of water per molecule of pantoprazole sodium, which can affect the physical properties and stability of the drug.

Chemical Properties

Pantoprazole sodium sesquihydrate is a white to off-white crystalline powder. It is soluble in water and slightly soluble in ethanol. The chemical structure of pantoprazole sodium sesquihydrate includes a pyridine and a benzimidazole ring. It is a proton pump inhibitor that works by irreversibly binding to the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell.

Structure

The molecular formula of pantoprazole sodium sesquihydrate is C16H15F2N3NaO4S x 1.5H2O, and its molecular weight is 432.4 g/mol. It contains one sodium cation, two fluorine atoms, one sulfur atom, three oxygen atoms, three nitrogen atoms, and sixteen carbon atoms in its structure.

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Pharmacological Effects

Pantoprazole Sodium Sesquihydrate is a proton pump inhibitor that works by decreasing the amount of acid produced in the stomach. It selectively inhibits the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. This results in a reduction in gastric acid secretion, providing relief from symptoms of gastroesophageal reflux disease (GERD) such as acid reflux and heartburn.

The pharmacological effects of pantoprazole sodium sesquihydrate include:

  • Reduction of Gastric Acid Secretion: Pantoprazole inhibits the final step of acid production in the stomach, leading to a decrease in the amount of acid produced.
  • Healing of Erosive Esophagitis: Pantoprazole can help heal damage to the esophagus caused by stomach acid, providing relief from symptoms and promoting mucosal healing.
  • Treatment of Helicobacter pylori Infection: Pantoprazole is often used in combination with antibiotics to eradicate H. pylori bacteria, which can help reduce the risk of peptic ulcers and gastric cancer.
  • Prevention of NSAID-Induced Ulcers: Pantoprazole is effective in preventing ulcers that may occur as a side effect of non-steroidal anti-inflammatory drugs (NSAIDs) by reducing gastric acid secretion.

Overall, pantoprazole sodium sesquihydrate’s pharmacological effects make it a valuable medication for managing acid-related disorders and promoting gastrointestinal health.

Administration and Dosage

Pantoprazole Sodium Sesquihydrate is usually administered orally, either with or without food, and should be swallowed whole with a glass of water. The dosage of pantoprazole sodium sesquihydrate depends on the condition being treated and the individual patient’s response to the medication.

For the treatment of GERD (Gastroesophageal Reflux Disease) and acid-related disorders:

  • Adults: The usual recommended dose is 40 mg once daily for 4 to 8 weeks. In some cases, a maintenance dose of 20 to 40 mg once daily may be prescribed.
  • Children (5 years and older): The recommended dose is based on weight. The usual starting dose is 20 mg once daily for up to 12 weeks.
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For the prevention of NSAID-induced peptic ulcer:

  • Adults: The usual dose is 20 mg once daily when NSAID therapy is initiated.

It is important to follow the prescribed dosage and duration of treatment as directed by your healthcare provider.

Administration and Dosage

Pantoprazole sodium sesquihydrate is typically administered orally in the form of delayed-release tablets.

Administration

Administration

The tablets should be taken whole with a glass of water, at least 1 hour before a meal. Do not crush, chew, or break the tablet.

Dosage

Dosage

The recommended dosage of pantoprazole sodium sesquihydrate may vary depending on the condition being treated. It is important to follow the instructions provided by your healthcare provider or pharmacist. Typically, the usual dose for adults is 40 mg once daily for up to 8 weeks for the treatment of gastroesophageal reflux disease (GERD).

For the maintenance therapy of GERD, the recommended dose is 40 mg once daily. Dosage adjustments may be necessary in elderly patients or those with renal impairment.

Side Effects and Precautions

Pantoprazole sodium sesquihydrate may cause some side effects, although not everyone experiences them. Common side effects include headaches, dizziness, gastrointestinal disturbances (such as diarrhea, constipation, nausea), and changes in taste sensation. These side effects are usually mild and temporary.

However, in rare cases, more serious side effects may occur, such as severe allergic reactions (e.g., rash, itching, swelling of the face, tongue, or throat), severe stomach pain, muscle weakness, and irregular heartbeat. If you experience any of these symptoms, seek medical attention immediately.

Precautions

Before taking pantoprazole sodium sesquihydrate, inform your healthcare provider about any allergies you may have, especially to proton pump inhibitors or any other medications. Tell your doctor about your medical history, especially if you have liver disease or osteoporosis.

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It is essential to follow the prescribed dosage and administration instructions carefully to avoid potential drug interactions or overdose. Do not abruptly stop taking pantoprazole without consulting your doctor, as it may lead to a rebound effect of the stomach acid. Pregnant or breastfeeding women should consult their doctor before using this medication.

Common Side Effects: Headaches Dizziness Gastrointestinal disturbances Changes in taste sensation
Severe Side Effects: Allergic reactions Severe stomach pain Muscle weakness Irregular heartbeat