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Pantoprazole Drug Card: Key Information
Pantoprazole is a proton pump inhibitor (PPI) used to treat certain stomach and esophagus problems such as acid reflux, ulcers, and Zollinger-Ellison syndrome.
Indications:
Pantoprazole is indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, and gastric ulcers caused by NSAIDs or H. pylori infection.
Usage:
Pantoprazole should be taken orally, usually once daily before a meal. It is important to swallow the tablets whole and not crush or chew them.
| Strengths Available | Recommended Dosage |
|---|---|
| 20 mg | Take one tablet daily for GERD |
| 40 mg | May be prescribed for more severe conditions |
Indications and Usage
Pantoprazole is indicated for the treatment of certain conditions in which there is an excess of stomach acid. It is commonly used to treat conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome.
It is also used in combination with antibiotics to treat Helicobacter pylori infection and to prevent stomach ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs).
Pantoprazole works by reducing the amount of acid produced in the stomach, helping to relieve symptoms and promote healing of the esophagus and stomach lining.
Dosage and Administration
It is important to follow the recommended dosage and administration guidelines when taking pantoprazole to ensure its effectiveness and minimize the risk of side effects.
| Indication | Dosage | Administration |
|---|---|---|
| Peptic Ulcer Disease | 40 mg once daily for 4-8 weeks | Take the medication in the morning before eating |
| Gastroesophageal Reflux Disease (GERD) | 20-40 mg once daily for 4-8 weeks | Take the medication before a meal |
| Helicobacter pylori Eradication | 40 mg twice daily in combination with antibiotics | Take pantoprazole with food |
| Zollinger-Ellison Syndrome | Initial dose of 80 mg once daily, dose adjustments may be needed | Take the medication on an empty stomach |
It is important to consult your healthcare provider for personalized dosage recommendations based on your medical condition and individual response to treatment.
Contraindications and Precautions
Pantoprazole should not be used in patients with known hypersensitivity to proton pump inhibitors or any of the inactive ingredients in the formulation. Patients with a history of severe allergic reactions to other drugs should use pantoprazole with caution.
Patients with liver disease or impaired liver function should be monitored closely while taking pantoprazole, as the drug is metabolized in the liver. Dose adjustments may be necessary in these patients.
Pantoprazole may interact with certain medications, such as warfarin, digoxin, and atazanavir, so close monitoring and potential dosage adjustments may be required when using these medications concomitantly with pantoprazole.
Pantoprazole should not be used concomitantly with atazanavir-containing products due to the risk of reduced atazanavir plasma levels and a loss of its therapeutic effect.
In patients with low magnesium levels or vitamin B12 deficiency, pantoprazole therapy may exacerbate these conditions, so monitoring levels of these electrolytes and vitamins is important during treatment.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking before starting pantoprazole therapy to avoid potential drug interactions and adverse effects.
Adverse Reactions and Side Effects
As with any medication, pantoprazole may cause adverse reactions and side effects in some individuals. Common side effects of pantoprazole may include headache, diarrhea, nausea, abdominal pain, and flatulence. In some cases, patients may experience more severe side effects such as allergic reactions, including rash, itching, and swelling of the face, tongue, or throat.
If you experience any severe or persistent side effects while taking pantoprazole, contact your healthcare provider immediately. It is important to report any adverse reactions to your healthcare provider to ensure appropriate management and treatment.
Drug Interactions
Pantoprazole may interact with other medications and substances, resulting in changes in its effectiveness or potential side effects. It is important to consult with a healthcare professional before starting pantoprazole if you are taking any other medications.
Some common drug interactions include:
- Warfarin: Pantoprazole may increase the risk of bleeding when taken with warfarin, a blood thinner. Close monitoring of blood clotting times is recommended.
- Clopidogrel: Co-administration of pantoprazole with clopidogrel, a platelet inhibitor, may decrease the effectiveness of clopidogrel. Consider alternative antiplatelet therapy.
- Methotrexate: Pantoprazole may increase blood levels of methotrexate, a chemotherapy drug, leading to toxicity. Dose adjustments may be necessary.
These are just a few examples of potential drug interactions with pantoprazole. Always inform your healthcare provider about all medications you are taking to avoid any adverse effects.
Storage and Handling
Store pantoprazole at room temperature away from moisture and heat.
Keep the medication in its original packaging to protect it from light.
Handling Instructions:
- Handle pantoprazole with clean and dry hands to avoid contamination.
- Avoid crushing or chewing the tablets. Swallow them whole with a full glass of water.